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Tuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant genetic disease that causes non-cancerous tumours to grow in the brain and on other vital organs such as the kidneys, heart, liver, eyes, lungs and skin.
The amygdala, cerebellum, and many other brain regions have been implicated in autism. [15]Unlike some brain disorders which have clear molecular hallmarks that can be observed in every affected individual, such as Alzheimer's disease or Parkinson's disease, autism does not have a unifying mechanism at the molecular, cellular, or systems level.
Autism spectrum disorder [a] (ASD), or simply autism, is a neurodevelopmental disorder "characterized by persistent deficits in social communication and social interaction across multiple contexts" and "restricted, repetitive patterns of behavior, interests, or activities". [11] Sensory abnormalities are also included in the diagnostic manuals ...
A 2018 review suggests that the frequent association of gastrointestinal disorders and autism is due to abnormalities of the gut–brain axis. [109] The "leaky gut syndrome" hypothesis developed by Andrew Wakefield, known for his fraudulent study on another cause of autism, is popular among parents of children with autism.
Iryna Spodarenko / GettyWe’ve come a long way in our understanding of autism since it was first used as a clinical description in 1943. Scientists have identified some of the genes that seem to ...
Hippocampal sclerosis is the most common brain abnormality in those with temporal lobe epilepsy. [16] Hippocampal sclerosis may occur in children under 2 years of age with 1 instance seen as early as 6 months. [17] About 70% of those evaluated for temporal lobe epilepsy surgery have hippocampal sclerosis.
Autism is associated with several genetic disorders, [4] perhaps due to an overlap in genetic causes. [5] About 10–15% of autism cases have an identifiable Mendelian (single-gene) condition, chromosome abnormality, or other genetic syndrome, [6] a category referred to as syndromic autism.
The Columbus Developmental Center (CDC) is a state-supported residential school for people with developmental disabilities, located in the Hilltop neighborhood of Columbus, Ohio. The school, founded in 1857, was the third of these programs developed by a U.S. state, after Massachusetts in 1848 and New York in 1851.