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Glucose transporter type 4 (GLUT4), also known as solute carrier family 2, facilitated glucose transporter member 4, is a protein encoded, in humans, by the SLC2A4 gene. GLUT4 is the insulin -regulated glucose transporter found primarily in adipose tissues and striated muscle (skeletal and cardiac).
TUG releases the GLUT4 containing vesicles (GSVs) in response to insulin stimulation which allows it to move to the plasma membrane. [2] TUG has an N-terminal ubiquitin-like protein domain (UBL1) which in similar proteins appears to participate in protein-protein interactions. [2]
GLUT4: Expressed in adipose tissues and striated muscle (skeletal muscle and cardiac muscle). Is the insulin-regulated glucose transporter. Responsible for insulin-regulated glucose storage. GLUT14: Expressed in testes: similarity to GLUT3 [12]
GLUT4 has a Km value for glucose of about 5 mM, which as stated above is the normal blood glucose level in healthy individuals. GLUT4 is the most abundant glucose transporter in skeletal muscle and is thus considered to be rate limiting for glucose uptake and metabolism in resting muscles. [ 8 ]
n/a Ensembl ENSG00000125520 n/a UniProt Q9NR83 n/a RefSeq (mRNA) NM_020062 n/a RefSeq (protein) NP_064446 n/a Location (UCSC) Chr 20: 63.74 – 63.74 Mb n/a PubMed search n/a Wikidata View/Edit Human SLC2A4 regulator is a protein that in humans is encoded by the SLC2A4RG gene. The protein encoded by this gene is a nuclear transcription factor involved in the activation of the solute carrier ...
AS160 (Akt substrate of 160 kDa), which was originally known as TBC1 domain family member 4 (TBC1D4), [5] is a Rab GTPase-activating protein that in humans is encoded by the TBC1D4 gene.
n/a Ensembl n/a n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a n/a Wikidata View/Edit Human Glucose transporter 1 (or GLUT1), also known as solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), is a uniporter protein that in humans is encoded by the SLC2A1 gene. GLUT1 facilitates the transport of glucose across ...
David Ernest James FAA (born in Sydney in 1958) is a cell biologist who discovered the glucose transporter GLUT4.He has also been responsible for the molecular dissection of the intracellular trafficking pathways that regulate GLUT4 translocation to the cell surface, the topological mapping of the insulin signal transduction pathway, the creation of a method for studying in vivo metabolism in ...