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Complex chromosomal rearrangements (CCR) are rarely seen in the general population and are defined as structural chromosomal rearrangements with at least three breakpoints with exchange of genetic material between two or more chromosomes. [5] Some forms of campomelic dysplasia, for example, result from CCRs. [citation needed]
In gene conversion, a section of genetic material is copied from one chromosome to another, without the donating chromosome being changed. Gene conversion occurs at high frequency at the actual site of the recombination event during meiosis. It is a process by which a DNA sequence is copied from one DNA helix (which remains unchanged) to ...
Dual inheritance theory (DIT), also known as gene–culture coevolution or biocultural evolution, [1] was developed in the 1960s through early 1980s to explain how human behavior is a product of two different and interacting evolutionary processes: genetic evolution and cultural evolution.
Recurrent rearrangements are nucleotide sequence variations found in multiple individuals, sharing a common size and location of break points. [4] Therefore, multiple patients may manifest with similar deletions or duplications, resulting in the description of genetic syndromes.
[1] [2] [3] Chromoplexy causes genetic material from one or more chromosomes to become scrambled as multiple strands of DNA are broken and ligated to each other in a new configuration. In prostate cancer, chromoplexy may cause multiple oncogenic events within a single cell cycle, providing a proliferative advantage to a (pre-)cancerous cell.
The newly synthesized gene normally contains a novel gene expression or molecular function. The result of the neomorphic mutation is the gene where the mutation occurs has a complete change in function.
DJ recombination is followed (as above) with V β-to-D β J β rearrangements. All gene segments between the V β-D β-J β gene segments in the newly formed complex are deleted and the primary transcript is synthesized that incorporates the constant domain gene (V β-D β-J β-C β). mRNA transcription splices out any intervening sequence and ...
However, genomic rearrangement is also thought to be a driving force in evolutionary development as it gives rise to novel gene combinations. [5] Recombination hotspots may arise from the interaction of the following selective forces: the benefit of driving genetic diversity through genomic rearrangement coupled with selection acting to ...