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The paclitaxel-eluting Taxus stent received FDA approval and was launched in the US in 2004, [145] after a series of trials that compared it with a bare metal stent in various settings. The trials showed a significant reduction in target lesion revascularization and major adverse cardiac events with the Taxus stent at 9 and 12 months.
The first stent was patented in 1972 by Robert A. Ersek, MD based on work he had done in animals in 1969 at the University of Minnesota. In addition to intervascular stents, he also developed the first stent-supported porcine valve that can be implanted transcutaneously in 7 minutes, eliminating open-heart surgery. [37]
A heart attack during or shortly after the procedure occurs in 0.3% of cases; this may require emergency coronary artery bypass surgery. [13] Heart muscle injury characterized by elevated levels of CK-MB, troponin I, and troponin T may occur in up to 30% of all PCI procedures. Elevated enzymes have been associated with later clinical outcomes ...
Former President Bill Clinton, 63, who had two stents put into a native coronary artery in his heart on Thursday, was undergoing what's become a common proceudre to clear plaque buildup after ...
Paclitaxel is used as an antiproliferative agent for the prevention of restenosis (recurrent narrowing) of coronary and peripheral stents; locally delivered to the wall of the artery, a paclitaxel coating limits the growth of neointima (scar tissue) within stents. [23] Paclitaxel drug-eluting stents for coronary artery placement are sold under ...
Angioplasty is used to treat venous stenosis affecting dialysis access, with drug-coated balloon angioplasty proving to have better 6 month and 12 month patency than conventional balloon angioplasty. [13] Angioplasty is occasionally used to treat residual subclavian vein stenosis following decompression surgery for thoracic outlet syndrome. [14]
An example of a drug-eluting stent. This is the TAXUS Express 2 Paclitaxel-Eluting Coronary Stent System, which releases paclitaxel. Coronary artery disease is not currently reversible and eventually requires surgical management if it progresses.
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