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A domino effect is the cumulative effect produced when one event sets off a series of similar [1] or related events, a form of chain reaction. The term is an analogy to a falling row of dominoes . It typically refers to a linked sequence of events where the time between successive events is relatively short.
Cumulative effects, also referred to as cumulative environmental effects and cumulative impacts, can be defined as changes to the environment caused by the combined impact of past, present and future human activities and natural processes. Cumulative effects to the environment are the result of multiple activities whose individual direct ...
A cumulative or overall constant, given the symbol β, is the constant for the formation of a complex from reagents. For example, the cumulative constant for the formation of ML 2 is given by M + 2 L ⇌ ML 2; [ML 2] = β 12 [M][L] 2. The stepwise constant, K, for the formation of the same complex from ML and L is given by
Additive effect can be used to detect synergy as it can be considered as the baseline effect in methods determining whether drugs have synergistic effect. Synergistic effect is similar to additive effect, having a combination effect greater than additive effect. It can produce an effect of 2+2 > 4 when two drugs are used together.
By considering the cumulative effect of multiple exposures, it provides a holistic approach to the study of gene-environment interactions, allowing for a more accurate assessment [6] of disease risk and the identification of potential intervention strategies. [7] Environmental exposures can have a significant impact on an individual's health.
Jannik Bjerrum (son of Niels Bjerrum) developed the first general method for the determination of stability constants of metal-ammine complexes in 1941. [1] The reasons why this occurred at such a late date, nearly 50 years after Alfred Werner had proposed the correct structures for coordination complexes, have been summarised by Beck and Nagypál. [2]
A simple example is provided by the effect of replacing the hydrogen atoms in acetic acid by the more electronegative chlorine atom. The electron-withdrawing effect of the substituent makes ionisation easier, so successive pK a values decrease in the series 4.7, 2.8, 1.4, and 0.7 when 0, 1, 2, or 3 chlorine atoms are present. [49]
It reflects the cumulative effect of the individual half-lives, as observed by the changes in the actual serum concentration of a drug under a given dosing regimen. The complexity of biological systems means that most pharmacological substances do not have a single mechanism of elimination, and hence the observed or effective half-life does not ...