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Plasmid-mediated resistance is the transfer of antibiotic resistance genes which are carried on plasmids. [1] Plasmids possess mechanisms that ensure their independent replication as well as those that regulate their replication number and guarantee stable inheritance during cell division.
The gene cassettes may encode genes for antibiotic resistance, [9] although most genes in integrons are uncharacterized. An attC sequence (also called 59-be) is a repeat that flanks cassettes and enables cassettes to be integrated at the attI site, excised and undergo horizontal gene transfer.
However, bacteria can also acquire resistance through transformation, as in Streptococcus pneumoniae uptaking of naked fragments of extracellular DNA that contain antibiotic resistance genes to streptomycin, [158] through transduction, as in the bacteriophage-mediated transfer of tetracycline resistance genes between strains of S. pyogenes ...
Inter-bacterial gene transfer was first described in Japan in a 1959 publication that demonstrated the transfer of antibiotic resistance between different species of bacteria. [ 29 ] [ 30 ] In the mid-1980s, Syvanen [ 31 ] postulated that biologically significant lateral gene transfer has existed since the beginning of life on Earth and has ...
MRSA is any strain of S. aureus that has developed (through natural selection) or acquired (through horizontal gene transfer) a multiple drug resistance to beta-lactam antibiotics. Beta-lactam (β-lactam) antibiotics are a broad-spectrum group that include some penams ( penicillin derivatives such as methicillin and oxacillin ) and cephems such ...
(A) The vertical gene transfer of a toxin-antitoxin system. (B) Horizontal gene transfer of a toxin-antitoxin system. PSK stands for post-segregational killing and TA represents a locus encoding a toxin and an antitoxin. [1] A toxin-antitoxin system consists of a "toxin" and a corresponding "antitoxin", usually encoded by closely linked genes ...
Integrons: These are gene cassettes that usually carry antibiotic resistance genes to bacterial plasmids and transposons. [15] Introns: Group I and II introns are nucleotide sequences with catalytic activity that are part of host transcripts and act as ribozymes that can invade genes that encode tRNA, rRNA, and proteins. They are present in all ...
Antibiotic resistance is the most commonly used marker for prokaryotes. The transforming plasmid contains a gene that confers resistance to an antibiotic that the bacteria are otherwise sensitive to. The mixture of treated cells is cultured on media that contain the antibiotic so that only transformed cells are able to grow.