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In September 2001, letters containing anthrax spores were mailed to several news media offices and two U.S. Senators, killing five people and infecting 17 others. Of those infected, 11 developed cutaneous anthrax, while 11 developed inhalation anthrax. 20 of the 22 infected worked at a site where contaminated mail was handled or received. [7]
Anthrax meningoencephalitis is also nearly always fatal. [72] Gastrointestinal anthrax infections can be treated, but usually result in fatality rates of 25% to 60%, depending upon how soon treatment commences. Injection anthrax is the rarest form of anthrax, and has only been seen to have occurred in a group of heroin injecting drug users. [70]
Anthrax is a disease caused by Bacillus anthracis, a spore-forming, Gram positive, rod-shaped bacterium (Fig. 1).The lethality of the disease is caused by the bacterium's two principal virulence factors: (i) the polyglutamic acid capsule, which is anti-phagocytic, and (ii) the tripartite protein toxin, called anthrax toxin.
The symptoms in anthrax depend on the type of infection and can take anywhere from 1 day to more than 2 months to appear. All types of anthrax have the potential, if untreated, to spread throughout the body and cause severe illness and even death. [24] Four forms of human anthrax disease are recognized based on their portal of entry.
As vectors, the mites can transmit anthrax, leading to fatal infections in hosts whose immune systems are weakened by the mange. The high host specificity of the mites limits their impact to primarily even-toed ungulates. The last reported focus of infection occurred in the late 1950s among semi-domesticated reindeer.
Studies indicate that lead was very prominent in Roman beverages. This is mostly due to the lead-based storage containers that were popular during the time. [6] Some scholars speculate that the levels of alcohol consumed on a daily basis were more to blame for the health ailments of the aristocrats of Rome, with the average consumption rate being approximately 3 bottles of wine a day. [6]
Close contact with cattle can lead to cutaneous anthrax infection, whereas inhalation anthrax infection is more common for workers in slaughterhouses, tanneries and wool mills. [5] Methicillin-resistant Staphylococcus aureus (MRSA) has been identified in pigs and humans raising concerns about the role of pigs as reservoirs of MRSA for human ...
Anthrax vaccines are used for both livestock and human immunization. One of the most used anthrax vaccines today is based on the Sterne strain, in the form of a live-spore vaccine for animals. A vaccine with live spores is dangerous for humans, so vaccines based on the secreted toxin protein, protective antigen (PA), have been explored.