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Tail flick test apparatus. The tail flick test is a test of the pain response in animals, similar to the hot plate test. It is used in basic pain research and to measure the effectiveness of analgesics, by observing the reaction to heat. It was first described by D'Amour and Smith in 1941. [1]
In contrast to the tail flick assay, rodents are often unrestrained while the radiant heat source is focused on the hindpaw. Cut-off latency for the Hargreaves assay is commonly set at 10 seconds. [7] The main advantage of this test over the tail flick assay is that it allows independent assessment of treatment effects on both sides of the body ...
Of Mice and Men is a 1937 novella written by American author John Steinbeck. [ 1 ] [ 2 ] It describes the experiences of George Milton and Lennie Small, two displaced migrant ranch workers, as they move from place to place in California , searching for jobs during the Great Depression .
Nonhuman animal pain measurement techniques include the paw pressure test, tail flick test, hot plate test and grimace scales. Grimace scales are used to assess post-operative and disease pain in mammals. Scales have been developed for ten mammalian species such as mice, rats, and rabbits. [68]
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The hot plate test is a test of the pain response in animals, similar to the tail flick test. Both hot plate and tail-flick methods are used generally for centrally acting analgesic, [1] while peripherally acting drugs are ineffective in these tests but sensitive to acetic acid-induced writhing test. [2] The hot plate test is used in basic pain ...
Of Mice and Men is a play adapted from John Steinbeck's 1937 novel of the same name. The play, which predates the Tony Awards and the Drama Desk Awards, earned the 1938 New York Drama Critics' Circle Best Play.
The main strength of the tail suspension test is its predictive validity– performance on the test can be altered by drugs that improve depressive symptoms in people. Specifically, if antidepressant agents are administered before the test, the animal will struggle for a longer period of time than if not and exhibit more escape behaviors. [1]