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Amantadine was initially developed to prevent replication of the influenza A virus. [18] Its main clinical use today is treatment of Parkinson's disease. [18] Other uses include treatment of drug-induced extrapyramidal side effects, motor fluctuations during levodopa therapy in Parkinson's disease, traumatic brain injury, and autistic spectrum disorders.
A wakefulness-promoting agent (WPA), or wake-promoting agent, is a drug that increases wakefulness and arousal. [1] [2] [3] They are similar to but distinct from psychostimulants, which not only promote wakefulness but also produce other more overt central nervous system effects, such as improved attention span, executive functions, vigilance and motivation.
The wakefulness-promoting agent modafinil and its analogues (e.g., adrafinil, armodafinil) have been approved to treat narcolepsy and shift work sleep disorder. [6] These act as weak ( micromolar ) DRIs, [ 7 ] but this effect does not correlate with wakefulness-promoting effects, suggesting the effect is too weak to be of clinical significance.
On a basic level, a sleep study uses monitoring devices to track things like your brain waves, heart rate, breathing rate, and muscle movement over the course of one night. These tests may be done ...
Wakefulness is a daily recurring brain state and state of consciousness in which an individual is conscious and engages in coherent cognitive and behavioral responses to the external world. Being awake is the opposite of being asleep, in which most external inputs to the brain are excluded from neural processing. [1] [2] [3] [4]
The Cancer Prevention Diet: 6 Smarts Tips From A Nutritionist On What To Eat And Why Here’s the full list of items that Patidar said she’s eliminated — and her replacements for them. 1.
Researchers discovered that amantadine and memantine bind to and act as agonists of the σ 1 receptor (K i = 7.44 μM and 2.60 μM, respectively) and that activation of the σ 1 receptor is involved in the central dopaminergic effects of amantadine at therapeutically relevant concentrations; the authors of the study stated that this could also ...
The refrain of parents is “I love all my children equally.” But not all kids get treated equally. Experts explain the impact of preferential treatment in a family.
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