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The choice between the drugs is to a large degree determined by the characteristics of the patient being prescribed for, the drugs' side effects, and cost. Most drugs have other uses; sometimes the presence of other symptoms can warrant the use of one particular antihypertensive. Examples include: Age can affect the choice of medications.
Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]
As can be seen in table 1, these drugs are highly plasma protein-bound and therefore oral administration once a day should provide sufficient antihypertensive effects. [1] Around 14% of orally ingested losartan is metabolized to its 5-carboxylic acid metabolite EXP 3174.
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This antihypertensive compound is a precursor to the drug candesartan, and as such, possess a biphenyl-tetrazole moiety similar to other AT 1 R blockers. ZD7155 was shown to make several key interactions within the active sight, revealing the binding mode of AT 1 R blockers. Structure of AT 1 R with ZD7155 in the active site. PDB: 4YAY
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It is used to treat hypertension as monotherapy or in combination with other antihypertensive agents. [7] [39] The key to the discovery of aliskiren was crystallography and molecular modeling techniques. Now, a solution has been found to the problem that impeded the development of the renin inhibitors of the previous generations.