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The cell cycle inhibitor p27kip1 has also been found to encourage regrowth of cochlear hair cells in mice following genetic deletion or knock down with siRNA targeting p27. [36] [37] Research on hair cell regeneration may bring us closer to clinical treatment for human hearing loss caused by hair cell damage or death.
The organ of Corti is located in the scala media of the cochlea of the inner ear between the vestibular duct and the tympanic duct and is composed of mechanosensory cells, known as hair cells. [2] Strategically positioned on the basilar membrane of the organ of Corti are three rows of outer hair cells (OHCs) and one row of inner hair cells ...
Three rows consist of outer hair cells (OHCs) and one row consists of inner hair cells (IHCs). The inner hair cells provide the main neural output of the cochlea. The outer hair cells, instead, mainly 'receive' neural input from the brain, which influences their motility as part of the cochlea's mechanical "pre-amplifier".
The hair cells are the primary auditory receptor cells and they are also known as auditory sensory cells, acoustic hair cells, auditory cells or cells of Corti. The organ of Corti is lined with a single row of inner hair cells and three rows of outer hair cells. The hair cells have a hair bundle at the apical surface of the cell.
The cochlear duct contains the organ of Corti. [2] [5] This is attached to the basilar membrane. [5] It also contains endolymph, which contains high concentrations of K + for the function of inner hair cells and outer hair cells in the organ of Corti. [2]
The hair cells are attached to the basilar membrane, and with the moving of the basilar membrane, the tectorial membrane and the hair cells are also moving, with the stereocilia bending with the relative motion of the tectorial membrane. This can cause opening and closing of the mechanically gated potassium channels on the cilia of the hair ...
The stria vascularis produces endolymph for the scala media, one of the three fluid-filled compartments of the cochlea. [4] This maintains the ion balance of the endolymph that surround inner hair cells and outer hair cells of the organ of Corti. [4] It secretes lots of K +, [1] [4] and may also secrete H +. [1]
In the mammalian cochlea, each outer hair cell stands on the soma of a cell of Deiters. What is not apparent in this diagram is that the phalangeal process is tilted out of the plane of this projection, such that its top is near the top of a different outer hair cell, further along in the directional of cochlear wave propagation.