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Loperamide, sold under the brand name Imodium, among others, [1] is a medication of the opioid receptor agonist class used to decrease the frequency of diarrhea. [5] [4] It is often used for this purpose in irritable bowel syndrome, inflammatory bowel disease, short bowel syndrome, [4] Crohn's disease, and ulcerative colitis. [5]
The expense of opioid replacement treatments in some countries has led some people to try treatments with limited evidence. At high doses, loperamide has been reported by some drug users to alleviate opioid withdrawal syndrome. [31] The doses reported in the literature are associated with a high risk of damage to the heart. [32]
Antimotility agents are drugs used to alleviate the symptoms of diarrhea. These include loperamide (Imodium), bismuth subsalicylate (Pepto-Bismol), [1] diphenoxylate with atropine (Lomotil), and opiates such as paregoric, tincture of opium, codeine, and morphine.
For example, most opioids cause sedation when given at a sufficiently high dose, but peripherally selective opioids can act on the rest of the body without entering the brain and are less likely to cause sedation. [1] These peripherally selective opioids can be used as antidiarrheals, for instance loperamide (Imodium). [2]
Alosetron was originally approved by the U.S. Food and Drug Administration (FDA) on February 9, 2000, [8] after a seven-month review. [9] At the time of the initial approval U.S. Food and Drug Administration (FDA) reviewers found that alosetron improved symptoms in 10% to 20% of patients. [10] Shipment to pharmacies started in March, 2000.
Recent research has found that high-dose prescription amphetamines, often used to treat ADHD, are linked to a seriously heightened risk of psychosis. High-dose ADHD drugs linked to 81% higher ...
Repeated administration of a medication is also different from single dosing, as many drugs have active metabolites that can build up in the body. [6] Patient variables such as sex, age, and organ function may also influence the effect of the drug on the system. These variables are rarely included in equianalgesic charts. [7] [3] [8]
Gary Sinise is getting candid about stepping away from Hollywood.. The Forrest Gump star, 69, shared in an interview with Fox News that his decision to take a break from his career in 2019 came ...
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