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The Dermatology Branch investigates fundamental and clinical aspects of neoplastic and inflammatory skin disease as well as normal skin function, while also providing all dermatology patient care at the NIH Clinical Center. The Branch includes research focused on clinical and translational research in rare disease populations, including new ...
At any given time, NIGMS supports more than 3,000 investigators and 4,000 research grants—around 11 percent of the total number of research grants funded by NIH as a whole. Additionally, NIGMS supports approximately 26 percent of the NRSA trainees who receive assistance from NIH. [1]
FACT (facilitates chromatin transcription, [1] sometimes facilitates chromatin transactions [2] [3]) is a heterodimeric protein complex that affects eukaryotic RNA polymerase II (Pol II) transcription elongation both in vitro and in vivo.
The institute provides informational fact sheets [8] that explain biomedical and bioengineering research topics, such as Computational Modeling, Drug Delivery Systems, Image-Guided Robotic Interventions, Magnetic Resonance Imaging (MRI), Mammography, Rehabilitation Engineering, and Tissue Engineering and Regenerative Medicine. The institute ...
n/a Ensembl ENSG00000143631 n/a UniProt P20930 n/a RefSeq (mRNA) NM_002016 n/a RefSeq (protein) NP_002007 n/a Location (UCSC) Chr 1: 152.3 – 152.33 Mb n/a PubMed search n/a Wikidata View/Edit Human Filaggrin (fil ament aggr egating prote in) is a filament-associated protein that binds to keratin fibers in epithelial cells. Ten to twelve filaggrin units are post-translationally hydrolyzed ...
This gene encodes a cytoplasmic protein known the neurofibromin, which functions as a tumor suppressor and therefore serves as a signal regulator of cell proliferation and differentiation. [ 18 ] [ 19 ] A dysfunction or lack of neurofibromin can affect regulation, and cause uncontrolled cell proliferation, leading to the tumors (neurofibromas ...
Myelinated neuron. HNPP is typically caused by autosomal dominant deletion of PMP22 (peripheral myelin protein 22 at locus 17p11.2). [9] PMP22 displays haploinsufficiency, such that the normal copy of the gene's activity is insufficient to compensate for loss of function of the affected copy. [10]
Elaine V. Fuchs is an American cell biologist known for her work on the biology and molecular mechanisms of mammalian skin and skin diseases, who helped lead the modernization of dermatology. Fuchs pioneered reverse genetics approaches, which assess protein function first and then assess its role in development and disease.