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Clostridioides difficile (syn. Clostridium difficile) is a bacterium known for causing serious diarrheal infections, and may also cause colon cancer. [ 4 ] [ 5 ] It is known also as C. difficile , or C. diff ( / s iː d ɪ f / ), and is a Gram-positive species of spore -forming bacteria. [ 6 ]
Clostridioides difficile infection [5] (CDI or C-diff), also known as Clostridium difficile infection, is a symptomatic infection due to the spore-forming bacterium Clostridioides difficile. [6] Symptoms include watery diarrhea, fever, nausea, and abdominal pain. [1] It makes up about 20% of cases of antibiotic-associated diarrhea. [1]
Clostridium butyricum MIYAIRI 588 strain is marketed in Japan, Korea, and China for Clostridium difficile prophylaxis due to its reported ability to interfere with the growth of the latter. [citation needed] Clostridium histolyticum has been used as a source of the enzyme collagenase, which degrades animal tissue. Clostridium species excrete ...
The bacteria can be found in humans, vertebrates, manure, soil and hydrothermal vents. Peptostreptococcaceae metabolize via fermentation producing a variety of short-chain fatty acids. [2] The bacteria are important in the digestion process of many ruminants, and in the oral health of vertebrates. Shape of the bacteria varies from cocci, rods ...
Overuse of antibiotics can cause imbalance of the gut microbiome, leading to overgrowth of the species Clostridioides difficile causing a serious infection (CDI). [12] Effects of this infection include severe diarrhea and the severity of many bowel related diseases is also increased as a result of the infection.
The genus Clostridioides was created to describe a few species formerly in the genus Clostridium which have been shown to be their own genetically distinct genus using 16S rRNA gene sequencing analysis. [1] However, both names are still in use and valid under the International Code of Nomenclature of Prokaryotes. [2]
Genus Clostridioides: Clostridium difficile and C. mangenotii, reassigned in 2016. [4] Genus Filifactor: Clostridium villosum, reassigned in 1994. Genus Maledivibacter: Clostridium halophilum, reassigned in 2016. Genus Paraclostridium: Clostridium bifermentans, reassigned in 2016.
The Clostridioides difficile TcdE Holin (TcdE Holin) Family is a group of transporters belonging to the Holin Superfamily IV. [1] A representative list of its members can be found in the Transporter Classification Database. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus.