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Procaine is a local anesthetic drug of the amino ester group. It is most commonly used in dental procedures to numb the area around a tooth [1] and is also used to reduce the pain of intramuscular injection of penicillin. Owing to the ubiquity of the trade name Novocain or Novocaine, in some regions, procaine is referred to generically as ...
Alternatively, the free base can be obtained using an organic chemistry technique called trituration. Trituration of the free base from cocaine hydrochloride (or "cooking") is done by dissolving the cocaine hydrochloride in water over constant heat, while simultaneously adding a base (such as baking soda) to form the free base cocaine.
Pseudocholinesterase deficiency results in delayed metabolism of only a few compounds of clinical significance, including the following: succinylcholine, mivacurium, procaine, heroin, and cocaine. Of these, its most clinically important substrate is the depolarizing neuromuscular blocking agent, succinylcholine , which the pseudocholinesterase ...
It is a form of penicillin which is a salt of benzylpenicillin and the local anaesthetic agent procaine. [9] The salt has weak solubility, and is prepared as a suspension. Upon injection it forms a deposit within tissue (a "depot'), and the salt slowly dissolves into interstitial fluid - dissociating the two molecules into their bioactive forms over an extended pe
Diethylethanolamine reacts with 4-aminobenzoic acid to make procaine. DEAE is a precursor for DEAE-cellulose resin, which is commonly used in ion exchange chromatography. it can decrease the surface tension of water when the temperature is increased. [3] Solutions of DEAE absorb carbon dioxide (CO 2).
Procaine (PCA) is a demethylating agent considered to be effective in inhibiting the growth of human cancer cells. Several studies have explored and elucidated the effects of procaine on human liver cancer cells and breast cancer cells.
Procainamide, an amide, has a longer duration of action than Procaine, an ester, because of the isosteric replacement of the ester oxygen with a nitrogen atom. [4] Procainamide is a classical bioisostere because the valence electron structure of a disubstituted oxygen atom is the same as a trisubstituted nitrogen atom, as Langmuir showed.
Procainamide is structurally similar to procaine, but in place of an ester group, procainamide contains an amide group. This substitution is the reason why procainamide exhibits a longer half-life time than procaine. [20] [21] Procainamide belongs to the aminobenzamides.