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Polymyxin B/trimethoprim, sold under the brand name Polytrim is an antimicrobial solution for topical ophthalmic use in the treatment of acute bacterial conjunctivitis and blepharoconjunctivitis. [1] In 2022, it was the 252nd most commonly prescribed medication in the United States, with more than 1 million prescriptions. [2] [3]
Other serious side effects may include fungal infections, anaphylaxis, and muscle weakness. [1] It is unclear if use during pregnancy is safe for the baby. [1] Polymyxin B works by breaking down the cytoplasmic membrane which generally results in bacterial cell death. [1] Polymyxin B was approved for medical use in the United States in 1964. [1]
Teeth discoloration and same side effects as tetracycline. Not to be given to children and pregnant or lactating women. Similar structure with tetracycline, but five times stronger, big volume distribution and long half-time in the body Tinidazole: Tindamax Fasigyn: Protozoal infections: Upset stomach, bitter taste, and itchiness: Trimethoprim(Bs)
Polymyxin B1, in turn, comprises several isomers, like isoleucine-polymyxin B1 and B1-1. [15] The major impediment in the purification and isolation of one isomer is due to the minimal structural differences between Polymyxin B1 and B2, differing only in one carbon at the 6th position of the fatty acyl side chain linked to the D-Phenylalanine ...
[1] [2] It contains the three antibiotics neomycin, polymyxin B, and bacitracin. [1] It is for topical use. [3] [4] Possible side effects include itchiness and skin rash, [5] and in rare cases hearing loss. [5] It is relatively broad spectrum, being effective against both Gram-negative and Gram-positive bacteria. [2]
New RSV vaccines are now available to help prevent serious infection in people over 60. Doctors explain the RSV vaccine and its side effects in older adults.
Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections. [1] Other uses include for middle ear infections and travelers' diarrhea . [ 1 ] With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS .
2. Acute Kidney Injury. Some reports in a review supported by Novo Nordisk suggested that semaglutide may decrease the risk of kidney disease over the long term. But there were also a few reports ...