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RNA polymerase II holoenzyme is a form of eukaryotic RNA polymerase II that is recruited to the promoters of protein-coding genes in living cells. [11] It consists of RNA polymerase II, a subset of general transcription factors , and regulatory proteins known as SRB proteins.
[5] [6] The core RNA polymerase complex forms a "crab claw" or "clamp-jaw" structure with an internal channel running along the full length. [7] Eukaryotic and archaeal RNA polymerases have a similar core structure and work in a similar manner, although they have many extra subunits.
5436 67710 Ensembl ENSG00000168002 ENSMUSG00000071662 UniProt P62487 P62488 RefSeq (mRNA) NM_002696 NM_026329 RefSeq (protein) NP_002687 NP_080605 Location (UCSC) Chr 11: 62.76 – 62.77 Mb Chr 19: 8.77 – 8.78 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA-directed RNA polymerase II subunit RPB7 is an enzyme that in humans is encoded by the POLR2G gene. This gene encodes the ...
Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of bacteriophage (including T7 RNA polymerase), mitochondrial polymerases of lower eukaryotes as well as chloroplastic RpoT polymerases.
5441 66491 Ensembl ENSG00000177700 ENSMUSG00000038489 UniProt P62875 P62876 RefSeq (mRNA) NM_021128 NM_025593 RefSeq (protein) NP_066951 NP_079869 Location (UCSC) Chr 11: 0.84 – 0.84 Mb Chr 7: 141.05 – 141.06 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA-directed RNA polymerases I, II, and III subunit RPABC5 is a protein that in humans is encoded by the POLR2L gene ...
RNA polymerase II holoenzyme is a form of eukaryotic RNA polymerase II that is recruited to the promoters of protein-coding genes in living cells. [ 1 ] [ 2 ] It consists of RNA polymerase II , a subset of general transcription factors , and regulatory proteins known as SRB proteins [ clarification needed ] .
The positive transcription elongation factor, P-TEFb, is a multiprotein complex that plays an essential role in the regulation of transcription by RNA polymerase II (Pol II) in eukaryotes. [1] Immediately following initiation Pol II becomes trapped in promoter proximal paused positions on the majority of human genes (Figure 1).
5430 20020 Ensembl ENSG00000284832 ENSG00000181222 ENSMUSG00000005198 UniProt P24928 P08775 RefSeq (mRNA) NM_000937 NM_009089 NM_001291068 RefSeq (protein) NP_000928 NP_001277997 Location (UCSC) Chr 17: 7.48 – 7.51 Mb Chr 11: 69.62 – 69.65 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that is encoded ...