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The goal of in situ muscle tissue engineering is to encourage host cell recruitment, natural scaffold formation, and proliferation and differentiation of host cells. The main idea which in situ muscle tissue engineering is based on is the self-healing, regenerative properties of the mammalian body. [26]
A muscle fiber and the motor neuron to which it is connected. [15] The spot at which the motor neuron attaches to the muscle fiber is known as the neuromuscular junction. When muscles receive information from internal or external stimuli, muscle fibers are stimulated by their respective motor neuron.
The stimulation of a mechanoreceptor causes mechanically sensitive ion channels to open and produce a transduction current that changes the membrane potential of the cell. [10] Typically the mechanical stimulus gets filtered in the conveying medium before reaching the site of mechanotransduction. [11]
Actin, alpha skeletal muscle is a protein that in humans is encoded by the ACTA1 gene. [5] [6] Actin alpha 1 which is expressed in skeletal muscle is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity.
Stretch-activated ion channels are required for the initial formation of an action potential from a mechanical stimulus, for example by the mechanoreceptors in vibrissae (whiskers) of some animals such as rodents. Afferent nerve fibers responsible for sensory stimulus detection and feedback are especially sensitive to stimulation.
Muscle tissue contains special contractile proteins called actin and myosin which interact to cause movement. Among many other muscle proteins, present are two regulatory proteins, troponin and tropomyosin. [1] Muscle tissue varies with function and location in the body. In vertebrates, the three types are: skeletal, cardiac (both striated), and
The muscle fibers belonging to one motor unit can be spread throughout part, or most of the entire muscle, depending on the number of fibers and size of the muscle. [2] [3] When a motor neuron is activated, all of the muscle fibers innervated by the motor neuron are stimulated and contract. The activation of one motor neuron will result in a ...
Mechanosensation is the transduction of mechanical stimuli into neural signals. Mechanosensation provides the basis for the senses of light touch, hearing, proprioception , and pain. Mechanoreceptors found in the skin, called cutaneous mechanoreceptors, are responsible for the sense of touch.