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Mitragynine is an indole-based alkaloid and is one of the main psychoactive constituents in the Southeast Asian plant Mitragyna speciosa, commonly known as kratom. [4] It is an atypical opioid that is typically consumed as a part of kratom for its pain-relieving and euphoric effects.
Mitragyna speciosa is a tropical evergreen tree of the Rubiaceae family (coffee family) native to Southeast Asia. [3] It is indigenous to Cambodia, Thailand, Indonesia, Malaysia, Myanmar, and Papua New Guinea, [4] where its leaves, known as kratom, have been used in herbal medicine since at least the 19th century. [5]
Columbus State Hospital, also known as Ohio State Hospital for Insane, was a public psychiatric hospital in Columbus, Ohio, founded in 1838 and rebuilt in 1877. [1] The hospital was constructed under the Kirkbride Plan. [2] The building was said to have been the largest in the U.S. or the world, until the Pentagon was completed in 1943. [3] [4]
This Sept. 27, 2017 file photo shows kratom capsules in Albany, N.Y. A U.S. government report released Thursday, April 11, 2019 said the herbal supplement was a cause in 91 overdose deaths in 27 ...
7-Hydroxymitragynine (7-OH) is a terpenoid indole alkaloid from the plant Mitragyna speciosa, commonly known as kratom. [2] It was first described in 1994 [3] and is a human metabolite metabolized from mitragynine present in the Mitragyna speciosa. 7-OH binds to opioid receptors like mitragynine, but research suggests that 7-OH binds with greater efficacy.
Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval.
OhioHealth Doctors Hospital is a 213-bed tertiary care teaching hospital located in Columbus in the U.S. state of Ohio. Doctors Hospital operates the second largest osteopathic medical training program in the United States. Each year, the hospital trains 160 physicians in residencies and fellowships.
Cone Health Behavioral Health Hospital (part of Cone Health), located at 700 Walter Reed Drive in Greensboro, North Carolina, is an 80-bed facility that specializes in helping children, adolescents and adults cope with mental health and/or addiction issues. Its comprehensive services focus on the total needs of the patient and their family.