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Gender-affirming hormone therapy (GAHT), also called hormone replacement therapy (HRT) or transgender hormone therapy, is a form of hormone therapy in which sex hormones and other hormonal medications are administered to transgender or gender nonconforming individuals for the purpose of more closely aligning their secondary sexual characteristics with their gender identity.
In pre-clinical models, testosterone XHT has been shown to lead to adverse cardiovascular effects, but adding a low-dose estrogen to that hormone therapy completely mitigated those effects. [45] (Goetz LG, et al. "Addition of Estradiol to Cross-sex Testosterone Therapy Reduces Atherosclerosis Plaque Formation in Female ApoE -/- Mice."
“Testosterone doesn’t drop off like estrogen does—it goes down a linear decline,” says Casperson. “Women in their mid-40s and 50s have half the testosterone that we had in our 20s.”
An individual who undergoes an orchiectomy will produce very little testosterone due to the removal of their testicles. This natural reduction in testosterone eliminates the need to take antiandrogen medication, which in turn can reduce the need to take supplemental estrogen medication. [2] [3] [4]
Fat cells produce an enzyme called aromatase, which converts testosterone to estrogen— and an imbalance in your testosterone and estrogen levels can increase body fat. High aromatase and ...
When men start testosterone therapy, it is typically given in a gel with a dose of 50-100 mg a day. Women, on the other hand, are recommended to take just 5 mg a day — 10% of the dose of a man.
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