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Metronidazole, sold under the brand name Flagyl among others, is an antibiotic and antiprotozoal medication. [10] It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis. [10]
Intravaginal administration is a route of administration where the substance is applied inside the vagina. Pharmacologically , it has the potential advantage to result in effects primarily in the vagina or nearby structures (such as the vaginal portion of cervix ) with limited systemic adverse effects compared to other routes of administration.
The chemical structure of ergosterol. The general mechanism of action for topical antifungal drugs is the disruption of the cell membrane.The unique components found in fungal cell membranes are usually the drug targets of antifungal drugs, in particular ergosterol.
One study found that vaginal irrigations with hydrogen peroxide (3%) resulted in a slight improvement, but this was much less than with the use of oral metronidazole. [72] Intravaginal boric acid, alone or in conjunction with other medications, may be helpful in the treatment of recurrent BV. [70] [73] [10]
Bacterial vaginosis: The most commonly used antibiotics are metronidazole, available in both pill and gel form, and clindamycin available in both pill and cream form. [11] Yeast infections: Local azole, in the form of ovula and cream. All agents appear to be equally effective. [33]
The hormonal gel is the most advanced in clinical trials, but it still hasn’t gone through a much larger, lengthy phase 3 trial. As of now — in part due to funding uncertainties — plans to ...
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