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Intravaginal administration is a route of administration where the substance is applied inside the vagina. Pharmacologically , it has the potential advantage to result in effects primarily in the vagina or nearby structures (such as the vaginal portion of cervix ) with limited systemic adverse effects compared to other routes of administration.
About 60% of the metronidazole is metabolized by oxidation to the main metabolite hydroxymetronidazole and a carboxylic acid derivative, and by glucuronidation. The metabolites show antibiotic and antiprotozoal activity in vitro. [61] Metronidazole and its metabolites are mainly excreted via the kidneys (77%) and to a lesser extent via the ...
In a double-blind study by Slavin in 1992, terconazole showed a 75% mycological cure over a short-term period (7–14 days) and 100% mycological cure over a long-term period (28–34 days). This study focused on the drug as an 80 mg vaginal suppository, taken three times overnight by 10 women. [ 4 ]
One study found that vaginal irrigations with hydrogen peroxide (3%) resulted in a slight improvement, but this was much less than with the use of oral metronidazole. [72] Intravaginal boric acid, alone or in conjunction with other medications, may be helpful in the treatment of recurrent BV. [70] [73] [10]
The Dow Jones Industrial Average is chock-full of industry-leading blue chip stocks-- many of which pay dividends.But the Dow tends to underperform the S&P 500 during growth-driven rallies when ...
A 2023 study found that people diagnosed with depression were more than twice as likely to be diagnosed with dementia later in life. Medication, therapy, and healthy habits like eating right, ...
By Hyunsu Yim. SEOUL (Reuters) -North Korean leader Kim Jong Un held a key policy-setting meeting of the country's ruling party last week ahead of the new year, state media KCNA reported on Sunday.
Bacterial vaginosis in pregnancy is an alteration of the normal vaginal microbiota of pregnancy. Intrauterine infections in pregnancy are caused by bacteria that cause inflammation. The women may experience few or no symptoms. This sometimes leads to chorioamnionitis and other negative pregnancy outcomes.