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Aldosterone synthase, also called steroid 18-hydroxylase, corticosterone 18-monooxygenase or P450C18, is a steroid hydroxylase cytochrome P450 enzyme involved in the biosynthesis of the mineralocorticoid aldosterone and other steroids. The enzyme catalyzes sequential hydroxylations of the steroid angular methyl group at C18 after initial 11β ...
It selectively stimulates secretion of aldosterone. The secretion of aldosterone has a diurnal rhythm. Control of aldosterone release from the adrenal cortex: [citation needed] The role of the renin–angiotensin system: Angiotensin is involved in regulating aldosterone and is the core regulator. Angiotensin II acts synergistically with potassium.
Familial hyperaldosteronism is a group of inherited conditions in which the adrenal glands, which are small glands located on top of each kidney, produce too much of the hormone aldosterone. [1] Excess aldosterone causes the kidneys to retain more salt than normal, which in turn increases the body's fluid levels and causes high blood pressure. [1]
Aldosterone has effects on most or all cells of the body but, clinically, the most important actions are in the kidney, on cells of the late distal convoluted tubule and medullary collecting duct. In the principal cells aldosterone increases activity of basolateral membrane sodium-potassium ATPase and apical epithelial sodium channels, ENaC ...
In aldosterone-producing adrenocortical adenoma (APA), which is the main cause of primary aldosteronism, the enzyme aldosterone synthase (CYP11B2) plays a crucial role in aldosterone production. Somatic mutations in genes like KCNJ5 and CACNA1D can lead to an overexpression of CYP11B2 and increased production of aldosterone.
On the verge of his 99th birthday, film legend Dick Van Dyke said he's not afraid to die.. The Emmy-winning actor starred in Coldplay's new music video for the track "All My Love," in which Van ...
A hacker gained access to an online secure document-sharing file between attorneys involved in a civil lawsuit brought by a close friend of former Rep. Matt Gaetz, according to sources familiar ...
The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate the mineralocorticoid receptor due to the non-selectivity of the receptor, leading to aldosterone-like effects in the kidney.