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According to a study in JAMA Dermatology, the prescribing rates of spironolactone for acne in women rose about 300% from 2017 to 2020.
Side effects of spironolactone in clinical studies for acne in women Side effect RCTs Tooltip Randomized controlled trials (n (ITT Tooltip Intention-to-treat analysis) = 326) Case series (n (ITT Tooltip Intention-to-treat analysis) = 663) Number % Number % Menstrual irregularities: 38: 13.4 (of 283) 216: 33.4 (of 646) Breast tenderness: 8: 2.5: ...
[145] [146] [147] However, a 2017 hybrid systematic review found that the incidence of depression in women treated with spironolactone for acne was less than 1%. [63] Likewise, a 10-year observational study found that the incidence of depression in 196 transgender women taking high-dose spironolactone in combination with an estrogen was less ...
There are also several oral contraceptives that are also FDA-approved to treat hormonal acne and are sometimes prescribed in conjunction with spironolactone. They work by regulating your hormones ...
Spironolactone blocks your sensitive receptors from your androgens (aka the "male" sex hormones), which helps reduce oil and acne. It's a once-a-day treatment that's typically super effective ...
A 2017 hybrid systematic review reported that data from 50 studies on androgen levels with spironolactone in women were equivocal. [67] A 1993 review reported that changes in hormone levels with spironolactone were very heterogeneous, with most changes not achieving significance. [16]
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