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Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of psychiatric drugs used primarily as antidepressants. [1] They act by antagonizing the α 2 -adrenergic receptor and certain serotonin receptors such as 5-HT 2A and 5-HT 2C , [ 1 ] but also 5-HT 3 , [ 1 ] 5-HT 6 , and/or 5-HT 7 in some cases.
A 2012 review focused on antidepressants and sleep found that mirtazapine reduced the time it took to fall asleep and improved the quality of sleep in many people with sleep disorders caused by depression, but that it could also disturb sleep in many people, especially at higher doses, causing restless leg syndrome in 8 to 28% of people and in ...
Also, currently available antidepressants all elicit undesirable side-effects, and new agents should be divested of the distressing side-effects of both first and second-generation antidepressants. [6] Another serious drawback of all antidepressants is the requirement for long-term administration prior to maximal therapeutic efficacy.
Antidepressant discontinuation syndrome (ADS) can cause a “brain zap” side effect after stopping Lexapro. Here’s what causes them, according to a psychiatrist.
Serotonin, a brain messenger that you might know as the "happy hormone" (along with dopamine and others), helps regulate your mood as well as other functions like memory, social behavior and sleep.
Sexual side effects. Some antidepressants, including commonly prescribed ones from the class known as SSRIs (selective serotonin reuptake inhibitors), can cause sexual side effects such as ...
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