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Liebig's law states that growth only occurs at the rate permitted by the most limiting factor. [2] For instance, in the equation below, the growth of population is a function of the minimum of three Michaelis-Menten terms representing limitation by factors , and .
Threshold dose is the minimum dose of drug that triggers minimal detectable biological effect in an animal. [1] At extremely low doses, biological responses are absent for some of the drugs. The increase in dose above threshold dose induces an increase in the percentage of biological responses. [ 2 ]
Increased Risk of Solid Cancer with Dose for A-bomb survivors, from BEIR report.Notably, this exposure pathway occurred from essentially a massive spike or pulse of radiation, a result of the brief instant that the bomb exploded, which while somewhat similar to the environment of a CT scan, is wholly unlike the low dose rate of living in a contaminated area such as Chernobyl, where the dose ...
Justus Freiherr von Liebig [a] (12 May 1803 – 20 April 1873) [2] was a German scientist who made major contributions to the theory, practice, and pedagogy of chemistry, as well as to agricultural and biological chemistry; he is considered one of the principal founders of organic chemistry. [3]
Arndt–Schulz rule or Schulz' law is a claimed law concerning the effects of pharmaca or poisons in various concentrations. It states that: [ 1 ] For every substance, small doses stimulate, moderate doses inhibit, large doses kill.
Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...
The ED 95 is the dose required to achieve the desired effect in 95% of the population. In anaesthesia, the term ED 95 is also used when referring to the pharmacology of neuromuscular blocking drugs. In this context, it is the dose which will cause 95% depression of the height of a single muscle twitch, in half of the population.
G-11 [5] The concept of limiting factors is based on Liebig's Law of the Minimum, which states that growth is controlled not by the total amount of resources available, but by the scarcest resource. In other words, a factor is limiting if a change in the factor produces increased growth, abundance, or distribution of an organism when other ...