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Protein folding problem: Is it possible to predict the secondary, tertiary and quaternary structure of a polypeptide sequence based solely on the sequence and environmental information? Inverse protein-folding problem: Is it possible to design a polypeptide sequence which will adopt a given structure under certain environmental conditions?
In solutions where two species are present (i.e. species A and species B), one species (A) may bind to the other species (B). In some cases, more than one A will bind with a single B. One way to determine the amount of A binding to B is by using a Job plot.
Gas stoichiometry is the quantitative relationship (ratio) between reactants and products in a chemical reaction with reactions that produce gases. Gas stoichiometry applies when the gases produced are assumed to be ideal, and the temperature, pressure, and volume of the gases are all known. The ideal gas law is used for these calculations.
For his 1934 paper, Alfred Redfield analyzed nitrate and phosphate data for the Atlantic, Indian, Pacific oceans and Barents Sea. [1] As a Harvard physiologist, Redfield participated in several voyages on board the research vessel Atlantis, analyzing data for C, N, and P content in marine plankton, and referenced data collected by other researchers as early as 1898.
ITC is a quantitative technique that can determine the binding affinity (), reaction enthalpy (), and binding stoichiometry of the interaction between two or more molecules in solution. [15] This is achieved by measuring the enthalpies of a series of binding reactions caused by injections of a solution of one molecule to a reaction cell ...
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A drop of indicator solution is added to the titration at the start; when the color changes the endpoint has been reached, this is an approximation of the equivalence point. Conductance The conductivity of a solution depends on the ions that are present in it. During many titrations, the conductivity changes significantly.
The laws of stoichiometry, that is, the gravimetric proportions by which chemical elements participate in chemical reactions, elaborate on the law of conservation of mass. Joseph Proust 's law of definite composition says that pure chemicals are composed of elements in a definite formulation.