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Short QT syndrome (SQT) is a very rare genetic disease of the electrical system of the heart, and is associated with an increased risk of abnormal heart rhythms and sudden cardiac death. [1] The syndrome gets its name from a characteristic feature seen on an electrocardiogram (ECG) – a shortening of the QT interval .
An "abnormal" QTc in males is a QTc above 450 ms; and, in females, above 470 ms. [17] If there is not a very high or low heart rate, the upper limits of QT can roughly be estimated by taking QT = QTc at a heart rate of 60 beats per minute (bpm), and subtracting 0.02 s from QT for every 10 bpm increase in heart rate.
It is one of the two most common valvular heart diseases in the elderly, [27] and the commonest type of valvular heart disease in low and middle income countries. [3] In a study of 595 male elite football players aged 18–38 and 47 sedentary non-athletes, mitral regurgitation was found in 20% football players and 15% in control group. Football ...
Long QT syndrome (LQTS) is a condition affecting repolarization (relaxing) of the heart after a heartbeat, giving rise to an abnormally lengthy QT interval. [7] It results in an increased risk of an irregular heartbeat which can result in fainting, drowning, seizures, or sudden death. [1]
Accessory pathways may not require any treatment, but those causing symptoms may be treated with medication including calcium channel antagonists, beta blockers or flecainide. [3] Alternatively, the electrical conduction through an accessory pathways can be abolished using catheter ablation , potentially offering a permanent cure.
Additionally, the weakened heart muscle may not be able to effectively pump blood to the lungs, leading to the accumulation of fluid in the lungs, a condition known as pulmonary edema. [7] Another potential complication of alcoholic cardiomyopathy is the development of arrhythmias, or abnormal heart rhythms. [7]
Mexiletine has several uses including the treatment of abnormal heart rhythms or arrhythmias, chronic pain, and myotonia. In general when treating arrhythmias, mexiletine is reserved for use in dangerous heart rhythm disturbances such as ventricular tachycardia. [3] It is of particular use when treating arrhythmias caused by long QT syndrome. [4]
In a normal heart, the heart rate is the rate at which the sinoatrial node depolarizes since it is the source of depolarization of the heart. Heart rate, like other vital signs such as blood pressure and respiratory rate, change with age. In adults, a normal heart rate is between 60 and 100 bpm (normocardic), whereas it is higher in children. [57]
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