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The choice between the drugs is to a large degree determined by the characteristics of the patient being prescribed for, the drugs' side effects, and cost. Most drugs have other uses; sometimes the presence of other symptoms can warrant the use of one particular antihypertensive. Examples include: Age can affect the choice of medications.
ATC code C02 Antihypertensives is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
Calcium channel blockers are used as antihypertensive drugs, i.e., as medications to decrease blood pressure in patients with hypertension. CCBs are particularly effective against large vessel stiffness, one of the common causes of elevated systolic blood pressure in elderly patients. [4]
Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]
Agents acting on the renin-angiotensin system (3 C, 3 P) Alpha blockers (2 C, 14 P) B. ... Antihypertensive agent stubs (93 P) Pages in category "Antihypertensive agents"
Many antiadrenergic agents used as antihypertensives include: Centrally acting Prazosin (α 1 inverse agonist) Rescinnamine (ACE inhibitor) Reserpine (VMAT inhibitor) Rilmenidine (imidazoline receptor agonist) Ganglion-blocking. Mecamylamine (α3β4 nicotinic receptor antagonist) Trimethaphan (ganglion type receptor antagonist) Peripherally acting
Moxonidine is a new-generation alpha-2/imidazoline receptor agonist antihypertensive drug licensed for the treatment of mild to moderate essential hypertension. [5] [6] It may have a role when thiazides, beta-blockers, ACE inhibitors, and calcium channel blockers are not appropriate or have failed to control blood pressure.
As can be seen in table 1, these drugs are highly plasma protein-bound and therefore oral administration once a day should provide sufficient antihypertensive effects. [1] Around 14% of orally ingested losartan is metabolized to its 5-carboxylic acid metabolite EXP 3174.