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cAMP-dependent pathway is necessary for many living organisms and life processes. Many different cell responses are mediated by cAMP; these include increase in heart rate, cortisol secretion, and breakdown of glycogen and fat. cAMP is essential for the maintenance of memory in the brain, relaxation in the heart, and water absorbed in the kidney ...
cAMP represented in three ways Adenosine triphosphate. Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger, or cellular signal occurring within cells, that is important in many biological processes. cAMP is a derivative of adenosine triphosphate (ATP) and used for intracellular signal transduction in many different organisms ...
At first, the PDE3s were purified and described as enzymes that hydrolyse both cGMP and cAMP with K m values of 0.1–0.8 μM. However the V max for cAMP hydrolysis is 4–10 times higher than V max for cGMP hydrolysis. [6] When different PDEs were first identified, two types of PDEs (PDE3 and PDE4) that exhibited high affinities for cAMP were ...
PKA is also commonly known as cAMP-dependent protein kinase, because it has traditionally been thought to be activated through release of the catalytic subunits when levels of the second messenger called cyclic adenosine monophosphate, or cAMP, rise in response to a variety of signals. However, recent studies evaluating the intact holoenzyme ...
cAMP-dependent pathway; Eph/ephrin signalling pathway; Hedgehog signalling pathway; Hippo signalling pathway; Insulin signal transduction pathway; JAK-STAT signalling ...
[1] cAMP primarily acts as an intracellular second messenger whose major intracellular receptor is the cAMP-dependent protein kinase (PKA) that acts through the phosphorylation of target proteins. [2] The signal transduction pathway begins with ligand-receptor interactions extracellularly.
The G s alpha subunit (G αs, G s α) is a subunit of the heterotrimeric G protein G s that stimulates the cAMP-dependent pathway by activating adenylyl cyclase.G s α is a GTPase that functions as a cellular signaling protein.
cAMP receptor protein (CRP; also known as catabolite activator protein, CAP) is a regulatory protein in bacteria. ... At most CRP-dependent promoters, ...