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Neuroinflammation is widely regarded as chronic, as opposed to acute, inflammation of the central nervous system. [5] Acute inflammation usually follows injury to the central nervous system immediately, and is characterized by inflammatory molecules, endothelial cell activation, platelet deposition, and tissue edema. [6]
While any nerve in the body may undergo inflammation, [10] specific etiologies may preferentially affect specific nerves. [11] The nature of symptoms depends on the specific nerves involved, neuritis in a sensory nerve may cause pain , paresthesia (pins-and-needles), hypoesthesia (numbness), and anesthesia , and neuritis in a motor nerve may ...
Neuritis is a general term for inflammation of a nerve [26] or the general inflammation of the peripheral nervous system. Symptoms depend on the nerves involved, but may include pain, paresthesia (pins-and-needles), paresis (weakness), hypoesthesia (numbness), anesthesia, paralysis, wasting, and disappearance of the reflexes. Causes of neuritis ...
Sensory loss, scarring and neuroma formation can cause morbidity to the donor site of the patient the nerve is harvested from. Therefore, alloplastic nerve graft research is being conducted for nerve repair. Silicone has been used previously, but long-term use of tubes produces compression and decreased conduction, requiring surgery to remove ...
Nerve growth factor (NGF) typically has a low level of expression in nerves that are healthy and not growing or developing, but in response to nerve injury NGF expression increases in Schwann cells. This is a mechanism to increase growth and proliferation of Schwann cells at the distal stump in order to prepare for reception of the regenerating ...
Complex regional pain syndrome is a multifactorial disorder with clinical features of neurogenic inflammation (inflammation mediated by nerve cells), nociceptive sensitisation (which causes extreme sensitivity or allodynia), vasomotor dysfunction (blood flow problems which cause swelling and discolouration) and maladaptive neuroplasticity ...
Joint pain is a common symptom we all experience at some point or another. Painful joints can have a significant impact on quality of life and the ability to do daily activities.
Pain is due to the release of chemicals such as bradykinin and histamine that stimulate nerve endings. [15] Acute inflammation of the lung (usually in response to pneumonia) does not cause pain unless the inflammation involves the parietal pleura, which does have pain-sensitive nerve endings. [15]