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Metformin is a diabetes drug that can help with insulin resistance. It can also help lower androgen levels. ... They can have effects on a developing fetus. Kateryna Onyshchuk/istockphoto.
If you’ve been prescribed metformin, it may be because you have prediabetes, type 2 diabetes, gestational diabetes, weight gain issues caused by antipsychotic medication or polycystic ovary ...
Metformin lowers the synthesis of glucose in liver and absorption of glucose from intestines. It also acquires an antilipolytic effect which reduces free fatty acid concentration. It is proved in many trials that Metformin can normalize menstrual function and raise the chance of ovulation. [33] [34]
Finally, the role of GLUT3/GLUT4 transport remains speculative. If the untreated gestational diabetes fetus is exposed to consistently higher glucose levels, this leads to increased fetal levels of insulin (insulin itself cannot cross the placenta). The growth-stimulating effects of insulin can lead to excessive growth and a large body .
One study among 96 patients diagnosed with gestational diabetes in the last three years found that, compared to insulin therapy, metformin had superior effects on blood sugar levels, inflammation ...
Metformin is a pleiotropic drug, with extensive off-target activity beyond its antidiabetic effect. Much of this has been attributed to its action on AMPK, although other mechanisms have been proposed. [221] [222] Metformin has been studied for its effects on multiple other conditions, including: Non-alcoholic fatty liver disease [223] [224] [225]
The use of metformin to control maternal blood glucose levels has shown to be more effective than using insulin alone in reducing the likelihood of fetal macrosomia. [41] There is a 20% lower chance of having an LGA baby when using metformin to manage diabetes compared to using insulin. [42]
Polycystic Ovary Syndrome (PCOS) Polycystic Ovary Syndrome (PCOS) is a condition in which your ovaries and adrenal glands produce more male hormones than normal and cysts develop on your ovaries.
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