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The pleural cavity, or pleural space (or sometimes intrapleural space), is the potential space between the pleurae of the pleural sac that surrounds each lung. A small amount of serous pleural fluid is maintained in the pleural cavity to enable lubrication between the membranes , and also to create a pressure gradient .
The combination of surface tension, oncotic pressure, and the fluid pressure drop caused by the inward elastic recoil of the lung parenchyma and the rigidity of the chest wall, results in a normally negative pressure of -5 cm H 2 O (approximately −3.68 mmHg or −0.491 kPa) within the pleural space, causing it to mostly stay collapsed as a ...
Heart rhythm disturbances have been seen among astronauts. Most of these have been related to cardiovascular disease, but it is not clear whether this was due to pre-existing conditions or effects of space flight. It is hoped that advanced screening for coronary disease has greatly mitigated this risk.
Heart failure is a leading cause of hospital readmissions in the U.S. People aged 65 and older were readmitted at a rate of 24.5 per 100 admissions in 2011. In the same year, heart failure patients under Medicaid were readmitted at a rate of 30.4 per 100 admissions, and uninsured people were readmitted at a rate of 16.8 per 100 admissions.
In patients with ischemic heart disease there is an accumulation of angiogenic growth factors in the pericardial fluid. These contribute to angiogenesis (the formation of new blood vessels) and arteriogenesis (the increase in diameter of existing arterioles). This helps to prevent myocardial ischemia (lack of oxygen to the heart). [6]
A transverse section of the thorax, showing the contents of the middle and the posterior mediastinum. The pleural cavity and the pericardial cavity are exaggerated since normally there is no space between the pleurae or between the pericardium and heart. Pericardium is also known as cardiac epidermis.
American astronaut Marsha Ivins demonstrates the effects of microgravity on her hair in space. The effects of spaceflight on the human body are complex and largely harmful over both short and long term. [1] Significant adverse effects of long-term weightlessness include muscle atrophy and deterioration of the skeleton (spaceflight osteopenia). [2]
[1] [2] The fluid in this space is called interstitial fluid, comprises water and solutes, and drains into the lymph system. [2] The interstitial compartment is composed of connective and supporting tissues within the body – called the extracellular matrix – that are situated outside the blood and lymphatic vessels and the parenchyma of organs.
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