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Amisulpride is approved and used at low doses in the treatment of dysthymia and major depressive disorder. [10] [20] [11] [21] [22] [23] Whereas typical doses used in schizophrenia block postsynaptic dopamine D 2-like receptors and reduce dopaminergic neurotransmission, low doses of amisulpride preferentially block presynaptic dopamine D 2 and D 3 autoreceptors and thereby disinhibit dopamine ...
The side effects of cyproterone acetate (CPA), a steroidal antiandrogen and progestin, including its frequent and rare side effects, have been studied and characterized.It is generally well-tolerated and has a mild side-effect profile, regardless of dosage, when it used as a progestin or antiandrogen in combination with an estrogen such as ethinylestradiol or estradiol valerate in women.
These side effects may occur in as many as 90% of men treated with bicalutamide monotherapy, [29] but gynecomastia is generally reported to occur in 70 to 80% of patients. [30] In the EPC trial, at a median follow-up of 7.4 years, breast pain and gynecomastia respectively occurred in 73.6% and 68.8% of men treated with 150 mg/day bicalutamide ...
Oral tablets containing 12.5 mg doxylamine succinate as well as oral capsules containing 25 mg doxylamine succinate were also previously available but were discontinued. [22] The combination of doxylamine and pyridoxine is available in the form of extended-and delayed-release oral tablets containing 10 to 20 mg doxylamine succinate and 10 to 20 ...
Weight gain or loss, which tends to be less significant than with SSRIs [32] Excepting effects on the liver, the above adverse effects were usually mild to moderate and occurred in the first two weeks of treatment, subsiding thereafter. [ 2 ]
Adverse effects Weight gain: 5 times more likely to have considerable weight gain, around 40% with chlorpromazine gaining weight: RR 4.9 CI 2.3 to 10.4: Very low (estimate of effect uncertain) Sedation: 3 times more likely to cause sedation, around 30% with chlorpromazine: RR 2.8 CI 2.3 to 3.5 Acute movement disorder
The side effects of trimipramine have been said to be similar to those of other tertiary amine TCAs, with a preponderance of anticholinergic and sedative effects. [9] However, trimipramine has also been said to be associated with a different side effect profile compared to other TCAs and in general with fewer side effects, chiefly due to its lack of norepinephrine reuptake inhibition and ...
[39] [40] It is available in 50 mg, 80 mg (in Japan), [48] and 150 mg tablets for oral administration. [ 82 ] [ 83 ] The drug is registered for use as a 150 mg/day monotherapy for the treatment of LAPC in at least 55 countries, [ 2 ] with the U.S. being a notable exception where it is registered only for use at a dosage of 50 mg/day in ...
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