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Apixaban is a highly selective, orally bioavailable, and reversible direct inhibitor of free and clot-bound factor Xa. Factor Xa catalyzes the conversion of prothrombin to thrombin, the final enzyme in the coagulation cascade that is responsible for fibrin clot formation. [ 27 ]
The p-methoxy group of apixaban connects to S1 pocket of FXa but does not appear to have any interaction with any residues in this region of FXa. The pyrazole N-2 nitrogen atom of apixaban interacts with Gln-192 and the carbonyl oxygen interacts with Gly-216. The phenyl lactam group of apixaban is positioned between Tyr-99 and Phe-174 and due ...
Side effects may include bleeding, most commonly from the nose, gastrointestinal tract (GI) or genitourinary system. [2] Compared to the risk of bleeding with warfarin use, direct factor Xa inhibitors have a higher risk of GI bleeding, but lower risk of bleeding in the brain. [2]
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FNF Week 7: San Diego 28, Santa Gertrudis 10. FNF Week 7: San Diego 28, Santa Gertrudis 10. Skip to main content. Sign in. Mail. 24/7 Help. For premium support please call: 800-290 ...
In April 2021, the developers announced plans to launch a Kickstarter project later in the month to turn the demo into a full game. [12] On April 18, a Kickstarter project for the full version of the game was released under the name Friday Night Funkin': The Full Ass Game and reached its goal of $60,000 within hours. [17]
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Friday Night Lights is an American sports drama television series developed by Peter Berg from a book and film of the same name. The series details events surrounding a high school football team from a fictional town called Dillon: a small, close-knit community in rural Texas.