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Acarbose is an oligosaccharide, whereas miglitol resembles a monosaccharide. Miglitol is fairly well absorbed by the body, as opposed to acarbose. Moreover, acarbose inhibits pancreatic alpha-amylase in addition to alpha-glucosidase, and is degraded by gut bacterial maltogenic alpha-amylase and cyclomaltodextrinase. [4] [5]
Miglitol is an oral alpha-glucosidase inhibitor used in the treatment of type 2 diabetes. It works by reversibly inhibiting alpha-glucosidase enzymes in the small intestine, which delays the digestion of complex carbohydrates and subsequently reduces postprandial glucose levels. [ 1 ]
Acarbose degradation is the unique feature of glycoside hydrolases in gut microbiota, acarbose degrading glucosidase, which hydrolyze acarbose into an acarviosine-glucose and glucose. [17] Human enzymes do transform acarbose: the pancreatic alpha-amylase is able to perform a rearrangement reaction , moving the glucose unit in the "tail" maltose ...
A new study finds that drinking carbonated or sparkling water may contribute to weight loss via two mechanisms, though it may need other factors to make a significant impact.
Alpha glucosidase inhibitors delay glucose absorption at the intestine level and thereby prevent sudden surge of glucose after a meal. [2] There are three major drugs which belong to this class, acarbose, miglitol and voglibose, [2] of which voglibose is the newest.
For example, if you’re also eating a fat- or fiber-rich food, the rate of protein absorption will slow down. Whether you are adding full-fat milk, chia seeds, ...
Alpha-glucosidase inhibitors (acarbose, miglitol, voglibose) Inhibit carbohydrate digestion in the small intestine by inhibiting enzymes that break down polysaccharides Slightly lower risk of hypoglycemia compared to sulfonylureas; Associated with modest weight loss; Decreases triglycerides; No detrimental effect on cholesterol
President Donald Trump fired the head of a U.S. watchdog agency focused on protecting government whistleblowers, the official said on Monday in a lawsuit alleging that his removal was unlawful.