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Glipizide, sold under the brand name Glucotrol among others, is an anti-diabetic medication of the sulfonylurea class used to treat type 2 diabetes. [1] [2] It is used together with a diabetic diet and exercise. [1] [2] It is not indicated for use by itself in type 1 diabetes. [1] [2] It is taken by mouth.
With dose-dependent concentrations the half-life is about 12–13 hours, Tmax 1–2 hours and it is protein-bound, so the medication has a rapid absorption and minimal excretion by the kidney. [ 49 ] Dapagliflozin disposition is not evidently affected by body mass index (BMI) or body weight , therefore the pharmacokinetic findings are expected ...
Absorption half-life 1 h, elimination half-life 12 h. Biological half-life ( elimination half-life , pharmacological half-life ) is the time taken for concentration of a biological substance (such as a medication ) to decrease from its maximum concentration ( C max ) to half of C max in the blood plasma .
A study confirmed that side effects like pancreatitis and kidney damage are possible while taking GLP-1s like Ozempic. Here's what a doctor wants you to know.
If you’ve been using a GLP-1 such as semaglutide, then you’ve likely experienced the powerful effects of this weight loss medication. You’re making smarter food choices, moving more, and ...
C-glucosides are more stable than o-glucosides which leads to modified half-life and duration of action. These modifications have also led to more specificity to SGLT-2. [9] C-glucosides that have heterocyclic ring at the distal ring or proximal ring are better when it comes to anti-diabetic effect and physicochemical features all together.
A comparable measurement is LCt 50, which relates to lethal dosage from exposure, where C is concentration and t is time. It is often expressed in terms of mg-min/m 3 . ICt 50 is the dose that will cause incapacitation rather than death.
Side effect may include low blood sugar, vomiting, abdominal pain, rash, and liver problems. [4] [7] Use by those with significant kidney problems or liver problems or who are pregnant is not recommended. [7] [4] Gliclazide is in the sulfonylurea family of medications. [7] It works mostly by increasing the release of insulin. [7]