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The US Food and Drug Administration (FDA) recommends avoiding the use of metformin in more severe chronic kidney disease, below the eGFR cutoff of 30 mL/minute/1.73 m 2. [88] Lactate uptake by the liver is diminished with metformin use because lactate is a substrate for hepatic gluconeogenesis, a process that metformin inhibits.
Kidney stone disease. Kidney stone disease, also known as renal calculus disease, nephrolithiasis or urolithiasis, is a crystallopathy where a solid piece of material (renal calculus) develops in the urinary tract. [ 2 ] Renal calculi typically form in the kidney and leave the body in the urine stream. [ 2 ]
Chronic metabolic acidosis commonly occurs in people with chronic kidney disease (CKD) with an eGFR of less than 45 ml/min/1.73m 2, most often with mild to moderate severity; however, metabolic acidosis can manifest earlier on in the course of CKD. Multiple animal and human studies have shown that metabolic acidosis in CKD, given its chronic ...
Metformin is the most commonly prescribed oral drug for diabetes. Of course, if you or a loved one receives treatment for diabetes, you probably already knew this. 7 Benefits of Metformin ...
[2] Blood tests may show impaired kidney function (elevated urea or creatinine) or electrolyte imbalances such as hyponatremia or hyperchloremic metabolic acidosis. Urinalysis may indicate an elevated pH due to the secondary destruction of nephrons within the affected kidney, which impairs acid excretion. Physical examination in a thin patient ...
Calculus (medicine) A calculus (pl.: calculi), often called a stone, is a concretion of material, usually mineral salts, that forms in an organ or duct of the body. Formation of calculi is known as lithiasis (/ ˌlɪˈθaɪəsɪs /). Stones can cause a number of medical conditions. Some common principles (below) apply to stones at any location ...
Urine pH may be monitored to help prevent the formation of kidney stones or to avoid side effects of some drugs, [68] such as high-dose methotrexate therapy, in which crystals that cause kidney damage can form if the urine is acidic. [69] If microscopy is performed, knowing the pH of the sample helps to identify any crystals that might be ...
Kidney. In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organs [1] that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation. [2][3] They are located on the left and right in the retroperitoneal space, and in adult humans are about 12 centimetres (41⁄2 inches) in ...
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