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The use of chan'su and love stone (a related toad skin preparation used as an aphrodisiac in the West Indies) has resulted in several cases of poisoning and at least one death. [25] [29] The practice of orally ingesting toad poison has been referred to in popular culture and in the scientific literature as toad licking and has drawn media ...
The parotoid gland (alternatively, paratoid gland) is an external skin gland on the back, neck, and shoulder of some frogs (especially toads), and salamanders. It can secrete a number of milky alkaloid substances (depending on the species) known collectively as bufotoxins , which act as neurotoxins to deter predation .
They occur in the parotoid glands, skin, and poison of many toads (Bufonidae family) and other amphibians, and in some plants and mushrooms. [ 1 ] [ 2 ] [ 3 ] The exact composition varies greatly with the specific source of the toxin.
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Unfortunately, this increased demand and use of the toads as a source of 5-MeO-DMT has put strain on their populations. [50] Concerned with the ecological impacts of the growing use of I. alvarius secretions as a source of 5-MeO-DMT, Ken Nelson would later advocate for the use of synthetic 5-MeO-DMT and conservation of the Colorado River Toad. [51]
The toad's primary defense system is glands that produce a poison that may be potent enough to kill a grown dog. [12] These parotoid glands also produce 5-methoxy-dimethyltryptamine (5-MeO-DMT) [13] and bufotenin (which is named after the Bufo genus of toads); both of these chemicals belong to the family of hallucinogenic tryptamines. Bufotenin ...