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Medetomidine is a veterinary anesthetic drug with potent sedative effects and emerging illicit drug adulterant. [ 1 ] It is a racemic mixture of two stereoisomers , levomedetomidine and dexmedetomidine , the latter being the isomer with the pharmacologic effect as an alpha 2- adrenergic agonist .
Noonan syndrome with multiple lentigines (NSML) which is part of a group called Ras/MAPK pathway syndromes, [2] is a rare autosomal dominant, [3] multisystem disease caused by a mutation in the protein tyrosine phosphatase, non-receptor type 11 gene . The disease is a complex of features, mostly involving the skin, skeletal and cardiovascular ...
Similar to xylazine, medetomidine causes negative health outcomes like sedation, slowed heart rate and difficulty breathing, symptoms that are further exacerbated when taken with opioid and non ...
The amount of medetomidine tested from overdose cases and drug seizures across the country has shown minor traces, according to a report by the Center for Forensic Science Research & Education ...
They are mainly used in research, having found limited clinical application in human medicine. They are extensively used in veterinary medicine to reverse the effects of alpha-2 agonist drugs used as sedatives, like xylazine, medetomidine and dexmedetomidine. Alpha-2 blockers increase noradrenaline release.
The rise of medetomidine comes as overdose deaths have fallen slightly. More than 107,000 people died of a drug overdose last year, down from about 111,000 in 2022, according to a recent report.
Rodent mite dermatitis (also known as rat mite dermatitis) is an often unrecognized ectoparasitosis occurring after human contact with haematophagous mesostigmatid mites that infest rodents, such as house mice, [1] rats [2] and hamsters. [3]
[10] [11] It is also used in humans to treat acute agitation associated with schizophrenia or bipolar disorder. [5] It is administered as an injection or intravenous solution or as a buccal or sublingual film. [1] Similar to clonidine, dexmedetomidine is a sympatholytic drug that acts as an agonist of α 2-adrenergic receptors in certain parts ...