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Most people with schizophrenia live independently with community support. [1] In people with a first episode of psychosis a good long-term outcome occurs in 42% of cases, an intermediate outcome in 35% of cases, and a poor outcome in 27% of cases. [7] Outcome for schizophrenia appear better in the developing than the developed world. [8]
Schizophrenia has been found to present cross-culturally, and it almost always has 0.1% prevalence in a given population, although some studies have cast doubts on this. It has been hypothesized that schizophrenia is unique to human beings and has existed for a long time. [1]
The authors conclude, "this study found evidence that humans can perform better than suggested by Matsuzawa in the limited-hold memory task. However, human performance is still below that of chimpanzees. This difference appears to stem from an inability to keep the location of symbols in working memory" [5]
Over the years, researchers had found that in people with schizophrenia, important parts of the brain are larger than usual, including the prefrontal cortex, which controls decision-making. Gray matter—the neural connections on which electrical signals travel, forming thoughts and emotions—is thinner.
The outcomes paradox (otherwise known as the "better prognosis hypothesis") is the observation that patients with schizophrenia in developing countries benefit much more from therapy than those in developed countries. This is surprising because the reverse holds for most diseases: "the richer and more developed the country, the better the ...
The evolution of schizophrenia refers to the theory of natural selection working in favor of selecting traits that are characteristic of the disorder. Positive symptoms are features that are not present in healthy individuals but appear as a result of the disease process.
Image credits: Chonky Woofers for my depression #2. My friend read reports about a stranded dog on Mt. Bross in Colorado and proceeded to climb the mountain and rescue said dog.
For a number of people, these effects were so severe that the researchers halted their driving tests, fearing someone would get into an accident. Because of these safety concerns, the FDA ended up approving the drug at a lower starting dosage than the company had requested—a dosage so low that a Merck scientist admitted it was “ineffective.”