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In cis women, spironolactone can cause menstrual irregularities, breast tenderness, and breast enlargement. [39] [64] [112] Aside from these adverse effects, the side effects of spironolactone in women taking high doses are minimal, and it is well tolerated. [64] [86] [113]
Description: Side effects of spironolactone (25–400 mg/day) with ≥1% incidence in a 2017 hybrid systematic review of clinical studies of spironolactone for acne in women. Side effects with <1% incidence included postural hypotension, depression, diarrhea, muscle pain, increased appetite, drowsiness, rashes/drug eruptions, chloasma-like skin ...
However, a small clinical study found that high doses of spironolactone had neither progestogenic nor antiprogestogenic effects in women. [16] [17] In any case, if one or both of these actions are clinically relevant, they might contribute to the menstrual irregularities and breast side effects of spironolactone.
When you start losing hair, Google quickly becomes your trusted advisor as you head toward Spiral City. This can be overwhelming, from looking up hair loss treatments to scouring social media.
These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the potential risks for future antipsychotics through more clinical trials and drug development.
As women begin to hit perimenopause and menopause, some start to question their identity, struggle with big life stressors like caring for aging parents, divorce, age discrimination at work, and ...
Eplerenone is a newer drug that was developed as a spironolactone analog with reduced adverse effects. In addition to the y-lactone ring and the substituent on C-7, eplerenone has a 9α,11α-epoxy group. This group is believed to be the reason why eplerenone has a 20-40-fold lower affinity for the mineralocorticoid receptor than spironolactone. [7]
Rare side effects may include high potassium levels and blood clots (when taken as a combined oestrogen-progestogen pill), among others. [ 4 ] [ 12 ] Drospirenone is a progestin, or a synthetic progestogen , and hence is an agonist of the progesterone receptor , the biological target of progestogens like progesterone . [ 1 ]