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This plot is colored such that those points having a fold-change less than 2 (log 2 = 1) are shown in gray. In statistics, a volcano plot is a type of scatter-plot that is used to quickly identify changes in large data sets composed of replicate data. [1] [2] It plots significance versus fold-change on the y and x axes
The plot visualizes the differences between measurements taken in two samples, by transforming the data onto M (log ratio) and A (mean average) scales, then plotting these values. Though originally applied in the context of two channel DNA microarray gene expression data, MA plots are also used to visualise high-throughput sequencing analysis ...
In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment.
Alternative splicing, alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single gene to produce different splice variants. For example, some exons of a gene may be included within or excluded from the final RNA product of the gene. [ 1 ]
The commonly used dual-flashlight plot is for the difference between two groups in high-throughput experiments such as microarrays and high-throughput screening studies, in which we plot the SSMD versus average log fold-change on the y- and x-axes, respectively, for all genes or compounds (such as siRNAs or small molecules) investigated in an ...
Volcano plot for the decomposition of formic acid on transition metals. In chemistry, the Sabatier principle is a qualitative concept in heterogeneous catalysis named after the French chemist Paul Sabatier. It states that the interactions between the catalyst and the reactants should be "just right"; that is, neither too strong nor too weak. If ...
In order to perform this analysis, a reference panel for gene expression should be obtained, such as an expression quantitative trait loci (eQTL), which helps to show gene expression regulation. [4] Using the reference panel, a predictive model can be generated to impute the expression variation of genes.
Volcano plot may refer to: . Sabatier principle - a concept in chemical catalysis that relates the optimal concentrations of catalysts and substrates; Volcano plot (statistics) - a type of graph used to relate fold-change to p-value that is commonly used in genomics and other omic experiments involving thousands of data-points