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Weight gain [20] There has been a study that suggests antipsychotics are associated with possible cortical reconfiguration and gray matter loss, [21] but correlational data also suggests patients who consume antipsychotics, like people with schizophrenia, tend to engage in unhealthy habits like smoking which may exacerbate gray matter loss. [22]
Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia). Typical antipsychotics may also be used for the treatment of acute mania, agitation, and other conditions.
Maintenance therapy with antipsychotic drugs is clearly superior to placebo in preventing relapse but is associated with weight gain, movement disorders, and high dropout rates. [40] A 3-year trial following persons receiving maintenance therapy after an acute psychotic episode found that 33% obtained long-lasting symptom reduction, 13% ...
It has been associated with significant weight gain. [13] Quetiapine binds D 1, D 2 and D 3 and can bind D 4 at high concentrations. [2] It is used to treat the positive symptoms of schizophrenia, [13] bipolar disorder and depression. [1] Of the second generation antipsychotics, quetiapine may produce fewer parkinsonian side effects. [24]
The two atypical antipsychotics with trials showing that had a low incidence of weight gain in large meta-analysis were lurasidone and aripiprazole. [69] In a meta-analysis of 18 antipsychotics, olanzapine and clozapine exhibited the worst metabolic parameters and aripiprazole, brexpiprazole, cariprazine, lurasidone, and ziprasidone the most ...
One theory to explain antidepressant-related weight gain is that psychotropic medications such as antidepressants can affect neurotransmitters involved in eating behavior, causing an increase in ...
Similarly, lurasidone should not be used to treat dementia-related psychosis, as evidence has shown increased mortality with antipsychotic use. [57] Weight gain is reported in up to 15 and 16 percent of users. [58] [59] Other possible side effects include vomiting, akathisia, dystonia, parkinsonism, somnolence, dizziness, sedation and nausea ...
However, not all antidepressants are equally likely to cause weight gain, and some are linked to weight loss in certain groups of people. For example, another study published in the International ...