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Perioperative stress dose of steroids to mitigate this rare but potentially fatal complications of perioperative use of steroid such as full-blown adrenal crisis in the perioperative period due to the secondary adrenal insufficiency. Various exogenous steroid preparations are used for a wide range of indications. [1]
Low-dose and high-dose variations of the test exist. [4] The test is given at low (usually 1–2 mg) and high (8 mg) doses of dexamethasone, and the levels of cortisol are measured to obtain the results. [5] A low dose of dexamethasone suppresses cortisol in individuals with no pathology in endogenous cortisol production.
Methylprednisolone (Depo-Medrol, Medrol, Solu-Medrol) is a synthetic glucocorticoid, primarily prescribed for its anti-inflammatory and immunosuppressive effects. [4] [5] [6] It is either used at low doses for chronic illnesses or used at high doses during acute flares.
General dosage ranges of anabolic steroids Medication Route Dosage range [a] Danazol: Oral: 100–800 mg/day Drostanolone propionate: Injection: 100 mg 3 times/week Ethylestrenol: Oral: 2–8 mg/day Fluoxymesterone: Oral: 2–40 mg/day Mesterolone: Oral: 25–150 mg/day Metandienone: Oral: 2.5–15 mg/day Metenolone acetate: Oral: 10–150 mg ...
If high doses were used for six to 10 days, reduce to replacement dose immediately and taper over four more days. Adrenal recovery can be assumed to occur within two to four weeks of completion of steroids. If high doses were used for 11–30 days, cut immediately to twice replacement, and then by 25% every four days.
In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. [ 1 ] A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e. have a long systemic half-life .
Historically, higher doses of steroids were given, but these have been suggested to be harmful compared to the lower doses which are advocated today. [ 23 ] In the CORTICUS study, hydrocortisone hastened the reversal of septic shock, but did not influence mortality, with an increased occurrence of septic shock relapse and hypernatremia . [ 20 ]
Megestrol acetate is used mainly as an appetite stimulant to promote weight gain in a variety of situations. [25] [26] [27] When given at very high dosages, it can substantially increase appetite in most individuals, even those with advanced cancer, and is often used to boost appetite and induce weight gain in patients with cancer or HIV/AIDS-associated cachexia. [25]