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They have been marketed as herbal incense, or "herbal smoking blends", [6] and sold under common names such as K2, spice, [8] and synthetic marijuana. [5] They are often labeled "not for human consumption" for liability defense. [ 8 ]
JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
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Mitragyna speciosa is a tropical evergreen tree of the Rubiaceae family (coffee family) native to Southeast Asia. [3] It is indigenous to Cambodia, Thailand, Indonesia, Malaysia, Myanmar, and Papua New Guinea, [4] where its leaves, known as kratom, have been used in herbal medicine since at least the 19th century. [5]
under the FDCA governing the sale and marketing of drugs, the provisions relevant to the off -label promotion of drugs, and the FDA’s response to date to the Caronia decision addressing the interplay between these provisions and the First Amendment. The Court then reviews the FDA’s evaluation
As Kanye West made a surprise return to the Grammys, his wife, Bianca Censori, made her debut at the ceremony wearing almost nothing.. On Sunday, Feb. 2, the couple arrived at the 2024 award show ...
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