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Periodic fever syndromes are a set of disorders characterized by recurrent episodes of systemic and organ-specific inflammation.Unlike autoimmune disorders such as systemic lupus erythematosus, in which the disease is caused by abnormalities of the adaptive immune system, people with autoinflammatory diseases do not produce autoantibodies or antigen-specific T or B cells.
Corticosteroids, Colchicine, Cimetidine. Periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome is a medical condition, typically occurring in young children, in which high fever occurs periodically at intervals of about 3–5 weeks, frequently accompanied by aphthous-like ulcers, pharyngitis and cervical adenitis (cervical ...
Familial Mediterranean fever. Familial Mediterranean fever has an autosomal recessive pattern of inheritance. Specialty. Rheumatology, Immunology. Familial Mediterranean fever (FMF) is a hereditary inflammatory disorder. [1]: 149 FMF is an autoinflammatory disease caused by mutations in Mediterranean fever gene, which encodes a 781–amino acid ...
The syndromes within CAPS overlap clinically, and patients may have features of more than one disorder. In a retrospective cohort of 136 CAPS patients with systemic involvement from 16 countries, [2] the most prevalent clinical features were fever (84% of cases, often with concurrent constitutional symptoms such as fatigue, malaise, mood disorders or failure to thrive), skin rash (either ...
PFAPA syndrome is a rare condition that tends to occur in children. [9] The name stands for "periodic fever, aphthae, pharyngitis (sore throat) and cervical adenitis" (inflammation of the lymph nodes in the neck). The fevers occur periodically about every 3–5 weeks.
Hobart Ansteth Reimann (1897–1986) was an American virologist and physician. Reimann made contributions to medicine with his 1938 landmark article [3] on atypical pneumonia (the "first description of virus pneumonia" [4]); and articles on periodic disease [5] and the common cold (1948). [6] He was active in the testing of streptomycin against ...
MKD is a periodic fever syndrome originally described in 1984 by the internist Jos van der Meer, [6] then at Leiden University Medical Centre. No more than 300 cases have been described worldwide. MKD was originally described as hyperimmunoglobulin D syndrome (HIDS), but HIDS is now recognized as a mild manifestation of MKD. [1]
Corticosteroids, NSAIDS [1] TNF receptor associated periodic syndrome (TRAPS[5]) is a periodic fever syndrome associated with mutations in a receptor for the molecule tumor necrosis factor (TNF) that is inheritable in an autosomal dominant manner. Individuals with TRAPS have episodic symptoms such as recurrent high fevers, rash, abdominal pain ...