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Anticoagulants come in many different forms, including injections, intravenous (IV) drugs, and medications you take by mouth. They often treat and prevent life-threatening conditions that can happen because of blood clots, like strokes, heart attacks and pulmonary embolisms.
Anticoagulants may be used to treat blood clots, or in conditions where the risk of blood clots is increased to reduce the risk. Examples of conditions where anticoagulants may be used include: Atrial fibrillation. Deep vein thrombosis (DVT) Hip or knee replacement surgery. Ischemic stroke.
Anticoagulation therapy is recommended for preventing, treating, and reducing the recurrence of venous thromboembolism, and preventing stroke in persons with atrial fibrillation.
This activity reviews the general principles in anticoagulation therapy, with highlights on the different types, indications, and perioperative impact of anticoagulants. Hemostasis involves an interplay of clotting factors and the vessel wall.
Anticoagulation therapy is the main treatment for VTE and must be applied with knowledge and skill in order to achieve the optimal balance between reduction in recurrent VTE and the risk of potentially life-threatening bleeding.
Topics addressed include (1) appropriate indications; (2) use in patients with specific comorbidities; (3) monitoring parameters; (4) transitioning between anticoagulant regimens; (5) major drug interactions; and (6) cost considerations.
Consequently, in recent years many novel anticoagulants have been developed. The emergency physician may institute anticoagulation therapy in the short term (e.g. heparin) for a patient being admitted, or may start a novel anticoagulation for a patient being discharged.
American Society of Hematology 2018 guidelines for management of venous thromboembolism: optimal management of anticoagulation therapy. Daniel M. Witt, Robby Nieuwlaat, Nathan P. Clark, Jack Ansell, Anne Holbrook, Jane Skov, Nadine Shehab, Juliet Mock, Tarra Myers, Francesco Dentali, Mark A. Crowther, Arnav Agarwal, Meha Bhatt, Rasha Khatib,
Anticoagulants are the cornerstone therapy for thrombosis prevention and treatment. While anticoagulants are commonly employed, their use is often associated with adverse drug events and increased readmission rates.
What are the highlights. Optimal care management of anticoagulation therapy in patients who have previously experienced a clot. Anticoagulant drugs must be used with skill in order to reduce risks of bleeding and developing another clot.