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Antibody tests may give false negative (no antibodies were detected despite the presence of HIV) results during the window period, hence an interval of three weeks to six months between the time of HIV exposure and the production of measurable antibodies to HIV seroconversion is implemented. Most people develop detectable antibodies ...
After seroconversion, the antibody is detectable by standard techniques and remains detectable unless the individual seroreverts, in a phenomenon called seroreversion, or loss of antibody detectability, which can occur due to weakening of the immune system or decreasing antibody concentrations over time. Seroconversion refers the production of ...
The window period for HIV may be up to three months, depending on the test method and other factors. RNA based HIV tests has the lowest window period. Modern and accurate testing abilities can cut this period to 25 days, 16 days, or even as low as 12 days, again, depending on the type of test and the quality of its administration and interpretation.
Acute HIV infection, primary HIV infection or acute seroconversion syndrome [1]: 416 is the first stage of HIV infection. It occurs after the incubation stage, before the latency stage, and the potential AIDS succeeding the latency stage.
This acute viremia is associated in virtually all people with the activation of CD8 + T cells, which kill HIV-infected cells, and subsequently with antibody production, or seroconversion. The CD8 + T cell response is thought to be important in controlling virus levels, which peak and then decline, as the CD4 + T cell counts rebound.
Indeed, time to HIV seroconversion can be determined only by a laboratory assessment which is usually initiated after a visit to the physician. Then one can only conclude that HIV seroconversion has happened between two examinations.
The median period of time between infection with HIV and the onset of clinically apparent disease is approximately 10 years in industrialized countries, according to prospective studies of homosexual men in which dates of seroconversion are known. Similar estimates of asymptomatic periods have been made for HIV-infected blood-transfusion ...
At this point, seroconversion, the development of antibodies, occurs and the CD4 T cell counts begin to recover as the immune system attempts to fight the virus, marking the HIV set point. The higher the viral load at the set point, the faster the virus will progress to AIDS ; the lower the viral load at the set point, the longer the patient ...