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A-971432 is an orally bioavailable selective agonist of sphingosine-1-phosphate receptor 5 (S1PR5) discovered at AbbVie. [1] It was discovered using high-throughput chemistry. [2]
Print/export Download as PDF; Printable version; In other projects Wikidata item; Appearance. ... Pages in category "Treatment of Alzheimer's disease"
Regarding incidence, cohort longitudinal studies (studies where a disease-free population is followed over the years) provide rates between 10 and 15 per thousand person-years for all dementias and 5–8 for AD, [235] [236] which means that half of new dementia cases each year are Alzheimer's disease. Advancing age is a primary risk factor for ...
Gantenerumab is a monoclonal antibody for the treatment of Alzheimer's disease being developed by Hoffmann-La Roche pharmaceuticals. [1] [2] Gantenerumab binds to and clears aggregated beta amyloid fibers. [3] A phase III clinical trial of gantenerumab was stopped early because of a lack of efficacy. [4]
Aducanumab, sold under the brand name Aduhelm, is an anti-amyloid drug designed to treat Alzheimer's disease. [2] [3] It is a monoclonal antibody [3] [2] that targets aggregated forms (plaque) [4] [5] of amyloid beta (Aβ) found in the brains of people with Alzheimer's disease to reduce its buildup.
Donepezil, sold under the brand name Aricept among others, is a medication used to treat dementia of the Alzheimer's type. [3] [4] [8] It appears to result in a small benefit in mental function and ability to function. [9] Use, however, has not been shown to change the progression of the disease. [10] Treatment should be stopped if no benefit ...
Psychological therapies for dementia are starting to gain some momentum. [when?] Improved clinical assessment in early stages of Alzheimer's disease and other forms of dementia, increased cognitive stimulation of the elderly, and the prescription of drugs to slow cognitive decline have resulted in increased detection in the early stages.
Current Alzheimer Research is a peer-reviewed medical journal covering the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer's disease. [ 3 ] Abstracting and indexing
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